The 2 meter social distance is a totally arbitrary statistical choice. But 'flattening the curve' (and thus not exceeding healthcare resources) is all about statistics. We need to assume there's an exponential fall-off of virus with distance from the 'proband' (infected person). The mechanics of how virus is mobilized (coughing v not, airway controlled or not, mask or not, large v small particles, dry air v moist, high v low temp) just determine the exponent of fall off with distance. We're beginning to learn about that. But even with distancing, most persons will have some kind of exposure at some time. Then you deal with the 'multiplicity of infection' ('MOI' / efficiency / how many particles does it take to give a 10%, 50% or 90% infection rate). Last, most important, and certainly least understood, is how does the individual's immune system respond to exposure. We've all been exposed to some variably related corona viruses, and then we each have immune systems that are as different as our fingerprints. All those things go into determining whether the individual clears the virus, or the other way round! My lab is working on characterizing such 'immune phenotypes' I'll let you know more in a couple of months - I hope - if we can get appropriate specimens.
Explaining the Pandemic to my Past Self
(CNN)US intelligence and national security officials say the United States government is looking into the possibility that the novel coronavirus originated in a Chinese laboratory rather than a market, according to multiple sources familiar with the matter who caution it is premature to draw any conclusions.
so moving
ooh, love this, marram‘I want to live, and I want to see a world without Donald f*cking Trump’ — NY journalist Sandi Bachom poured her heart out about losing friends to COVID-19 and the ‘horror movie’ we’re all living through pic.twitter.com/HQhon9xIkC— NowThis (@nowthisnews) April 16, 2020
Word of the Day: "marram" -- spiky grey-gold-green grass of dunes & coastal edges, the wefting roots of which together bind sands, stop shift & drift when the wind rises, when the storm lands.— Robert Macfarlane (@RobGMacfarlane) April 17, 2020
📷Peggy Choucair pic.twitter.com/EPgjxEEZx7
wtf?!
"People have been starved for content ... we're watching, like, reruns from the early 2000s," Gov. Ron DeSantis says of his bizarre decision to classify live pro wrestling shows as an "essential service" during a deadly pandemic pic.twitter.com/rWeCOJKkh2— Aaron Rupar (@atrupar) April 14, 2020
Inside the High Stakes New Life of a Coronavirus Specialist
One of the people saving the human race
ASSISTANT PROFESSOR
DEPARTMENT OF EPIDEMIOLOGY
Antibody delivery! In vivo testing starts tonight. Thanks Crowe lab! pic.twitter.com/FgoenNfkId— Lisa Gralinski (@LisaGralinski) April 11, 2020
This protein is the target of #remdesivir and #EIDD2801. #coronavirus #SARSCoV2 #COVID19 https://t.co/hsxjrrXLoV— Timothy Sheahan (@timothysheahan) April 11, 2020
Structure of the RNA-dependent RNA polymerase from COVID-19 virus | Science https://t.co/VYYKRSs83n— David R. Martinez, Ph.D. (@David_RMartinez) April 11, 2020
The military is already using remdesivir to treat its members, according to Quartz. Data on its effectiveness is expected next month.
huh, Remdesivir is an ebola treatment drug. huh, big bucks in antiviral med, "Gilead Sciences created and sells the world’s top-selling HIV medications, Truvada and Atripla, and commands about 75% of the U.S. treatment market and more than 50% worldwide."
Gilead Sciences (NASDAQ:GILD) has made remdesivir, its Ebola-turned-COVID-19 drug, available to more than 1,700 patients through compassionate-use and expanded-access programs, according to an update from Gilead's chairman and CEO, Daniel O'Day, that was posted on the company's website on Saturday
COVID-19 Treatment Update: Remdesivir, Hydroxychloroquine, Leronlimab, Ivermectin, and More
When given as a treatment 12 or 24 hours after infection has begun, EIDD-2801 can reduce the degree of lung damage and weight loss in mice. This window of opportunity is expected to be longer in humans, because the period between coronavirus disease onset and death is generally extended in humans compared to mice.
“This new drug not only has high potential for treating COVID-19 patients, but also appears effective for the treatment of other serious coronavirus infections,” said senior author Baric.
Compared with other potential COVID-19 treatments that must be administered intravenously, EIDD-2801 can be delivered by mouth as a pill. In addition to ease of treatment, this offers a potential advantage for treating less-ill patients or for prophylaxis — for example, in a nursing home where many people have been exposed but are not yet sick.
During a tense interview, Navarro challenged CBS correspondent Bill Whitaker: "Show me that episode, then you'll have some credence in terms of attacking the Trump administration for not being prepared." "60 Minutes" responded to that challenge and brought the receipts.
Remote work, automation, and telemedicine could soon become the new normal
ouch
A telltale sign of #COVID19: pernio / pseudo-chilblains— Ilan Schwartz MD PhD (@GermHunterMD) April 14, 2020
Painful, swollen and erythematous tips of toes (resembling frostbite).#DermTwitter #IDTwitter pic.twitter.com/4zplwrUiQ2
tee hee
your friend who thinks they already had it, maybe pic.twitter.com/D1i4wE8ikD— Matt Buechele (@mattbooshell) April 12, 2020
Halting funding for the World Health Organization during a world health crisis is as dangerous as it sounds. Their work is slowing the spread of COVID-19 and if that work is stopped no other organization can replace them. The world needs @WHO now more than ever.— Bill Gates (@BillGates) April 15, 2020
The death toll in NYC is shocking. If this city was a country, we'd have the sixth largest death toll in the world. About one in every 800 New Yorkers has died of the coronavirus.— Tom Gara (@tomgara) April 14, 2020
Frontline: SEASON 2020: EPISODE 18
How Satellite Images Reveal the Global Impact of the Coronavirus
So charming to see this Maine Coon cat go for a dip in a lake
Interesting to learn about how Siamese cats get their coloration
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